CHEM321 Organic Chemistry II

Chem: 321 Organic chemistry II Theme Functional group transformations. 

Objectives: To analyse the structure of given organic molecules and identify reaction centers. Recognize the reactivity pattern. Predict the outcome of the reaction. Explain the mechanism

Organic chemistry concepts related to functional group transformations will be discussed. A mechanism based approach will be adopted. Factors contributing to the reactivity pattern will be discussed. Discussion will be centered around analysis of structure of given organic substrate, identification of reactive parts of the molecule, recognizing the electronic nature of the reaction centers and reagents, predicting overall transformation and justifying the transformation. 

Teacher: Vasuki G


Unit I (Heterocycles) Chemistry of five and six–membered aromatic heterocycles with one hetero atom- synthesis and reactions of pyrrole, furan, thiophene, pyridine, indole, quinoline and isoquinoline and biologically important heterocycles (Chapter 27 of Bruice) 

Unit II (Carbohydrates and Lipids) Carbohydrates: Classification, configuration of aldoses and ketoses, reactions of monosaccharides, chain elangation, chain shortening, stereochemistry of glucose, the Fischer proof, cyclic structure of mono saccharides, formation of glycosides, reducing and non-reducing sugar, determination of ring size, di-saccharides and poly-saccharides. (Chapter 20 of Bruice.) Lipids: Fatty acids, waxes, fats and oils, membranes . (Chapter 24 of Bruice) 

Unit III (Amino acids, peptides and proteins) Classification and nomenclature of amino acids – configuration of amino acids, acid-base amino acids—isoelectric points—primary structure of peptides – end terminal analysis – peptides synthesis—secondary structure of proteins tertiary and quaternary structure of proteins. (Chapter 21 of Bruice.) 

Unit IV (Nucleosides, nucleotides and nucleic acids) Nucleosides and nucleotides, nucleic acids, helical forms of DNA, DNA replication. (Chapter 25 of Bruice). 

Unit V (Polymers and drugs) Introduction to synthetic polymers: General classes of synthetic polymers, chain growth polymers, stereo chemistry of polymerization, polymerization of dienes, co-polymers, step-growth polymers, physical properties of polymers, bio-degradable polymers. (Chapter 26 of Bruice) Introduction to organic chemistry of drugs: Naming drugs, lead compounds, molecular modification, random screening, serendipity in drug development, receptors, drugs as enzyme inhibitors, QSAR, anti-viral drugs (Chapter 30 of Bruice.) 

Teacher: Vasuki G