Course List

Site: Department of Chemistry, Pondicherry University
Course: Department of Chemistry, Pondicherry University
Book: Course List
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Date: Wednesday, 16 June 2021, 7:29 AM

1. CHEM100 General Chemistry laboratory I

Credits: 0-1-4-2

Prerequisite: None

1. Preparation of Exactly 0.10 N HCl

2. Checking purity with melting and boiling points

3. Qualitative visualization of exothermic and endothermic reactions

4. Estimation of anti-acid tablet

5. Estimation of water of crystallization of a hydrated salt

6. Estimation of molecular formula of an oxide

7. Density measurement of irregular objects using liquid displacement method

8. Preparation of soap from vegetable oils

 

2. CHEM120 General Chemistry Laboratory II

Credits: 0-1-4-2

Prerequisites: None

1. Identification of anions by chemical tests

2. Identification of cations by chemical tests

3. Identification of simple organic functional groups by chemical tests

4. Preparation of a simple polymer

5. Paper chromatographic separation of mixture of colured inks

6. Qualitative analysis of hardness of water by micellar effect – comparison of soaping effect of various commercial soaps/detergents

7. Qualitative identification of non-electrolyte, strong electrolytes, and weak electrolytes by electrical conductance.

 

3. CHEM200 Chemistry Laboratory III

Credits: 0-1-4-2

Prerequisites: None

1. Inorganic qualitative analysis: Identifying anions and cations present in the given mixture of inorganic salts. The mixture may contain an inferring anion. 

2. Volumetric analysis involving redox titrations, complexometric, and iodometry titrations.

 

4. CHEM210 Chemistry Laboratory IV

Credits: 0-1-4-2

Prerequisites: None

1) Identification of well known organic functional groups - Identification of elements present and functional groups.

2) Determination of phase transition temperature of phenol-water system.

3) Determination of equilibrium constant of \(I^{-} +I _{2} \leftrightharpoons I_{3}^{-}\)

4) Phase diagram of two component and three component systems.

5) Electrochemistry experiments. (i) Determination of electrode potential (ii) pH titration involving strong/weak acids and strong/weak bases (iii) Conductometry titration experiments (iv) Conductivity of weak and strong electrolytes

6) Mini-lab in organic synthesis (i)  Nitration of naphthalene (ii)   Ozazone formation (iii) Bromination of hydrocarbons. 

5. CHEM300 Chemistry Laboratory V

Credits: 0-1-6-3

Prerequisites: None

1. Gravimetric analysis: a) Estimation of barium ions as barium sulphate. b) Estimation of lead as lead chromate. c) Estimation of aluminium as its 8-hydroxyquinoline complex d) Estimation of Ni as Ni DMG complex.

2. Separation of given organic mixture and analysis.

3. Chromatographic techniques TLC, Paper and Column chromatography. 

4. Determination of first order rate constant. – Acid hydrolysis of ester

5. Determination of second order rate constant – Base hydrolysis of ester

6. Preparations of gels and colloids

6. CHEM310 Chemistry Laboratory VI

Credits: 0-1-6-3

Prerequisites: None

1) Separation of cations in a given mixture through ion exchange column and estimation by volumetric / gravimetric methods 

2) Extraction of caffeine 

3) Isolation of nucleic acid from banana 

4) One step synthesis of organic compounds a) Preparation of chalcone. b) Bromination of acetanilide c) Epoxidation reaction. d) Reduction of carbonyl compounds. e) Preparation of methyl orange. 

5) Experiments on analytical chemistry: 

a) Calibration of burette, pipette and standard measuring flask 

b) Estimation of errors from volumetric/gravimetric, and other experiments 

c) UV-Vis spectral recording for simple organic inorganic compounds/ions – Theory is not necessary. Experiment should familiarize the techniques to the students 

d) IR spectral recording for sample organic/inorganic compounds/ions – To familiarize the technique to the students 

e) Solvent extraction of selected organic/inorganic compounds/ions

7. CHEM101 General Chemistry – I

Credits: 3-1-0-3

Prerequisites: None

Unit-I (Fundamental concepts; Measurements in Chemistry; Language of Chemistry) Chemistry: Matter, Energy, Chemical and Physical Properties, Classifying Matter; Atoms and Molecules; Fundamental concepts and language of chemistry. (Chapter 1 and 2 of Robinson)

Unit - II (Atoms and molecules) Atomic and Molecular Masses: molecular formula determination, Stoichiometry and Chemical Change, quantitative analysis, Thermochemistry: enthalpyand its consequences Atoms: Structure and spectra, introduction to quantum theory, The Periodic Table: Electron Configuration and general properties (Chapters 3, 4, and 5 of Robinson) 

Unit – III (Chemical bonding; molecular structures and models of covalent bonds) Ionic Bonding, covalent bonding: oxidation states and Lewis symbol, Valence Bond Theory: Hybridization of Atomic Orbitals: sp Hybridization, sp 2 Hybridization, sp 3 Hybridization, sp 3 d and sp 3 d 2 Hybridization, Assignment of Hybrid Orbital to central atoms, Hybridization involving double and triple bonds. Molecular Orbital Theory: Molecular Orbitals, Molecular Orbital energy diagrams, Bond order, H2 and He 2 Molecules, Diatomic Molecules of the Second Period. (Chapters 6, 7 of Robinson) 

Unit – IV: (Gases, intermolecular forces, liquids and solids; solutions and colloids) The Macroscopic Behavior of Gases: Temperature, gas laws. The Microscopic Behavior of Gases: Kinetic and molecular theory of gases, intermolecular forces Properties of Liquids and Solids: forces between molecules, properties of liquidsand solids, structure of crystal and solids. The nature of solutions: The formation of solutions, dissolutions of ioniccompounds, dissolution of molecular electrolytes. Macroscopic Properties of Solutions: Solutions of gases in lipids, solutions ofliquids in lipids, the effect of temperature on the solubility of solids in water, solid solutions. Expressing Concentration: Percent composition, molarity, molality, mole fraction. Colligative Properties of Solutions, colloids chemistry (Chapters 10, 11, and 12 of Robinson) 

Unit – V (Introductory organic chemistry: Structure and bonding at carbon) Elemental carbons and compounds. Organic Compounds of Carbon: Alkanes, nomenclature, Hydrocarbons. Derivatives of aromatic and non-aromatic hydrocarbons. Polymers: Factors that affect properties of polymers, polymer properties, kinds of polymers (Chapters 9 and 24 of Robinson)

Text Book:

1. General Chemistry, W. R. Robinson, J. D. Odom, H. F. Holtzclaw, Jr., Tenth Edition, AITBS, Publishers, New Delhi.

Further Reading:

 General Chemistry, D. D. Ebbing, 7 Edition, AITBS Publishers, New Delhi. 

8. CHEM102 General Chemistry – II

Credits: 3-1-0-3

Prerequisites: None

Unit – I (Chemical thermodynamics; Electrochemistry; Oxidation – Reduction) The first law of thermodynamics, state functions. Work and heat Galvanic Cells and Cell Potentials: Galvanic cells, cell potentials, standard electrode potentials, circulation of cell potentials, relationship of the cell potential and the equilibrium constant.- Batteries: Primary cells, secondary cells, fuel cells, corrosion. Electrolytic cells: The electrolysis of molten sodium chloride, the electrolysis of aqueous solutions, electrolytic disposition of metals, Faraday’s Law of electrolysis. (Chapters 18 and 19 of Robinson) 

Unit – II (Introduction to nuclear chemistry) Stabilty of nuclei, nuclear reactions, nuclear energy, nuclear series, and other applications (Chapter 20) 

Unit – III (Chemistry of metals and semi-metals; co-ordination compounds) The elemental representative metals: Periodic relationships among groups, preparation of representative metals, chemical compounds The semi-metals: The chemical behavior and structures of the semi-metals, occurrence and preparation of boron and silicon, boron and silicon hydrides, boron and silicon halides, boron and silicon oxides and derivative. The transition elements, properties of the transition elements, preparation of the transition elements, compounds of the transition elements, copper oxide superconductors. Coordination compounds: Basic concepts, the naming of the complexes, the structures of complexes, isomerism in complexes, uses of complexes. Introduction to bonding: VSEPR, crystal field theory, properties and bonding (Chapter 22 and 23 of Robinson) 

 Unit – IV (Introductory organic chemistry: Structure and bonding at carbon; stereochemistry) Organic Compounds of Carbon: Alkanes, nomenclature, Hydrocarbons. Derivatives of aromatic and non-aromatic hydrocarbons - Polymers: Factors that affect properties of polymers, polymer properties, kinds of polymers - Stereochemistry of carbon compounds: stereo-structures – ways of representing stereo chemistry, stereo chemistry of simple hetero nuclear rings - Stereoisomerism: enantiomers and diastereomers; concept of chirality, priority rules. (Chapters 9 and 24 of Robinson) 

Unit – V (Organic reaction mechanisms) Types of organic reactions - addition, substitution, elimination reactions - interpretation of reaction profiles – Introductory treatment. (Chapter 9 of Robinson) 

Text Book: 

General Chemistry, W. R. Robinson, J. D. Odom, H. F. Holtzclaw, Jr., Tenth Edition, AITBS Publishers, New Delhi. 

 Further Reading: 

General Chemistry, D. D. Ebbing, 7 th Edition, AITBS Publishers, New Delhi.

9. CHEM201 Inorganic Chemistry I

Credits: 3-1-0-3

Prerequisites: None

Unit – I (Hydrogen and Hydrides, Alkali and Alkaline earth Metals) Hydrogen and Hydrides: Electronic structure, abundance, preparation and properties, isotopes, ortho- and para hydrogen; Hydrides: ionic, covalent, metallic and intermediate hydrides; Hydrogen bonding. Alkali metals: Introduction, halides, oxides and hydroxides, salts of oxo-acids, aqueous solution chemistry, complexes and organometallic compounds. Alkaline Earth metals: Introduction, halides, oxides and hydroxides, salts of oxo-acids, aqueous solution chemistry, complexes and organometallic compounds. 

Unit – II (Boron and Carbon group – Basic treatment) Boron group: Introduction, diborane and hydrogen compounds of the other elements, metal borides, halides and complex halides of B, Al, Ga, In and Tl, oxides, oxo-acids, oxoanions and hydroxides; nitrogen derivatives; Al, Ga, In and Tl salts of oxo-acids and aqueous solution chemistry, organometallic compounds. Carbon group: Introduction, Intercalation compounds of graphite, hydrides, carbides and silicides, halides and complex halides; oxides and oxo-acids of carbon; oxides and oxoacids and hydroxides of Si, Ge, Sn and Pb; Silicates; Silicones; Sulfides; Cyanogen, its derivatives and silicon nitride; aqueous solution chemistry and oxo-acid salts of Sn and Pb; Organometallic compounds. 

Unit – III (Nitrogen and Oxygen group- Basic treatment) Nitrogen group: Introduction; hydrides; nitrides, phosphides and arsenides; halides, oxohalides and complex halides; Oxides, oxo-acids and sulfides of N, P, As, Sb and Bi; Phosphazenes; Aqueous solution chemistry; Organic derivatives. Oxygen group: Introduction; Hydrides; Halides, Oxohalides and complex halides, Oxides, Oxo-acids and their salts; Sulphur-nitrogen compounds; Aqueous solution chemistry of S, Se and Te; Organic derivatives. 

Unit – IV (Halogens and noble gases- Basic treatement) Introduction; hydrogen halides; general considerations of halides; interhalogen compounds and polyhalogen ions; oxides and oxyfluorides of Cl, Br and I; oxo-acids of halogens and their salts; aqueous solution chemistry; organic derivatives. Noble gases: Introduction; compounds of Xe, Kr and Rn. 

Unit V (Nuclear Chemistry- Basic treatment) Introduction; nuclear binding energy; radio-activity and nuclear reactions; nuclear fission and fusion; spectroscopic techniques based on nuclear properties; separation of stable isotopes and unstable isotopes; applications of isotopes. 

Recommended Books: 

1. A. G. Sharpe, Inorganic Chemistry, 3 rd Edition, Addison-Wesley, 1999. 

2. J. D. Lee, A New Concise Inorganic Chemistry, 3rd Edition., ELBS, 1987. 

3. D. F. Shriver, P. W. Atkins, C. H. Langford, Inorganic Chemistry, ELBS. 1990.

10. CHEM222 ORGANIC CHEMISTRY I

Credits: 3-1-0-3

Prerequisites: None

Unit I (Introduction to Organic Chemistry) Introduction to functional groups, structure and bonding; isomers, nomenclature, and resonance; Intermolecular forces (Organic Chemistry by P.Y Bruice Chapter 1 and Chapter 2) 

Unit II (Chemical reactivity of organic molecules) Reaction Classification by Structural Change by Reaction Type; Acid-Base reactions, Oxidations & Reductions, Reaction Variables, Reactants & Reagents, Product Selectivity, Other Variables, Reaction Rate ,Intermediates, Reaction Energetics, Bond Energy, Electronic Effects, Steric Effects, Solvent Effects, Reaction Mechanisms, Curved Arrow Notation, Reactive Intermediates, Reaction Illustrations, Nucleophilicity & Basicity, Acid Base Catalysis (Organic Reactivity; Virtual text of organic chemistry) 

Unit III (Stereochemistry) Stereoisomers: Alkene Configurational Isomers, Cycloalkane Configurational Isomers Conformational Isomers: Ethane,Butane, Cycloalkanes, Substituted Cyclohexanes Chirality & Symmetry: Symmetry Elements, Enantiomorphism, Optical Activity, Configurational nomenclature, Compounds Having Two or More Stereogenic Centers, Fischer Projection Formulas, achiral diastereomers, Other Configurational Notations, Resolution Conformational Enantiomorphism (Chapter 2.9 – 2.15 and chapter 4 upto 4.13 of Bruice). 

Unit IV (Chemistry of non aromatic hydrocarbons) Nomencalture, synthesis and reactions of alkanes Nomenclature , synthesis and reactions of alkenes. Nomenclature , synthesis and reactions of alkynes Nomenclature , synthesis and reactions of dienes (Chapters 8,3, 5,6 and 7 of Bruice)  

Unit V (Chemistry of aromatic hydrocarbons) Aromaticity, Huckel Rule, resonance energy, Benzene structure and reactions, Naphthalene structure and reactions, Activity and orientation of substituted benzenes. (Chapters 14 and 15 of Bruice) 

Text book: 

Organic Chemistry, P. Y. Bruice, Pearson Education, 3 rd edition, 2006 

Further Reading 

1. Organic Chemistry; L.G. Wade, 5 th edition, Pearson Publications, 2003 

2. Organic Chemistry, Clayden, Greeves, Warren, Oxford University Press, 2001

11. CHEM242 Physical Chemistry I

Credits: 3-1-0-3

Prerequisites: PHYS102 Thermal Physics

Unit I (Solutions) Gibbs - Duhem equation - thermodynamics of mixing - Henry’s & Raoult’s laws - liquid mixtures - colligative properties - mixture of volatile liquids - distillation - azeotropes - solvent & solute activity, 

UNIT – II (Phase transformations) Stability of phases - Clapeyron equation - Clasius-Clapeyron equation. Thermodymamics of phase transition; classification of phases - bubbles, cavities and droplets-Kelvin equation, capillary action. 

UNIT – III (Phase diagrams) One component systems - two component systems - reactive systems - three component systems - Chemical equilibrium - equilibrium response to pressure - van’t Hoff relation - Ellingham diagram. 

UNIT – IV (Equilibrium electrochemistry-Ions in solution- 1) Activities in solutions - mean activity coefficient - Debye - HÜckel theory - role of electrodes - electrochemical potential - types of electrodes - kinds of cell - emf and electrode potentials - standard electrode potentials - thermodynamics of emf of cells – potentiometric titrations - pK & pH - acid base titrations – buffers. 

UNIT – V (Equilibrium electrochemistry-Ions in solution- 2) Ion transport and molecular diffusion: Ion motion - conductivity - mobilities - transport numbers and measurement - Debye Huckel Onsager theory - diffusion - Fick’s laws - diffusion and convection. 

Text Book: 

Physical Chemistry, P. W. Atkins, 7 th edition, Oxford Publications, 2006 

Further Reading: 

1. Physical Chemistry , Alberty, 5 th edition, Wiley Publications, 2005 

2. Physical Chemistry, by Thomas Engel and Reid, 1 edition, Pearson Education India, 2006

12. CHEM301 Inorganic Chemistry II

Credits: 3-1-0-3

Prerequisites: None

Unit – I (Coordination Compounds 1) Introduction, physical and chemical properties of transition elements; Introduction to coordination compounds; coordination numbers and geometries in transition metal complexes; nomenclature; isomerism in transition metal complexes – structural, geometrical and optical isomerism. 

Unit – II (Coordination Compounds 2) Double salts and coordination compounds; Werner’s work; effective atomic number; bonding in transition metal complexes – valence bond theory, crystal field theory (octahedral and tetrahedral complexes); magnetism. 

Unit – III (Transition Metals of the First Series) Introduction and the chemistry of Scandium, Titanium, Vanadium, Chromium, Manganese, Iron, Cobalt, Nickel, Copper and Zinc. 

Unit – IV (Transition Metals of the Second and Third Series) Introduction and the chemistry of Yttrium & Lanthanum, Zirconium & Hafnium, Niobium & Tantalum, Molybdenum & Tungsten, Technetium & Rhenium, Ruthenium & Osmium, Rhodium & Iridium, Palladium & Platinum, Silver and Gold, Cadmium & Mercury. 

Unit – V (Lanthanide and Actinide Elements) Lanthanides: Introduction, occurrence, separation, oxidation states and general chemistry. Actinides: Introduction, isolation and general chemistry. 

Text Book: 

D. F. Shriver, P. W. Atkins, C. H. Langford, Inorganic Chemistry, ELBS. 1990. 

Recommended Books: 

1. A. G. Sharpe, Inorganic Chemistry, 3 rd Edn., Addison-Wesley, 1999. 

2. J. D. Lee, A New Concise Inorganic Chemistry, 3rd Edn., ELBS, 1987. 

3. B. Douglas, D. McDaniel, J. Alexander, Concepts and Models of Inorganic Chemistry, 3rd Edn., John Wiley, 2001.

13. CHEM321 Organic chemistry II

Credits: 3-1-0-3

Prerequisites: None

Unit I (Reactions at sp hybridized carbon) Substitution reactions - SN1, SN2 reaction mechanism, factors influencing SN1 and SN2 reactions, elimination reaction E1, E2, E1cb reaction mechanisms factors affecting, substitutions vs eliminations. [Chapters 9, 10 and 11 of Bruice] 

Unit II (Organometallics of Groups I and II, boron, silicon, sulphur) Alkyl and aryl lithiums preparation and reactions, Grignard reagent synthesis and reactions, sulpur stabilized anions, sulphonium salts, sulphonium ylids, sulphur stabilizedcations carbonyl compounds, sulphoxides, borons - hydroborations, allyl and crotyl boranes, silicon - reactions of silanes and silyl enol ether. [Chapter 46 and 47 of Clayden] 

Unit III (Reactions of aldehydes and ketones) Reactions of carbonyl compounds with carbon, hydrogen, oxygen and nitrogen nucleo philes, reactions of α, β and unsaturated carbonyl compounds, reactions at the α-carbon[chapters 17 and 19 of Bruice] 

Unit IV (Reactions of carboxylic acids and their derivatives) Reactions of carboxylic acids and their derivatives with oxygen and nitrogen nucleophile– relative reactivities of carboxylic acid and its derivatives – general machanism of acylation reaction. [Chapter 16 of Bruice] 

Unit V (Introduction to spectroscopic identification of organic molecules) Mass spectrometry, infrared spectroscopy UV- Visible spectroscopy and NMR spectroscopy (Chapter 12 and 13 of Bruice) 

Text book: 

Organic Chemistry, P. Y. Bruice, Pearson Education, 3 rd edition, 2006 

Further Reading 

1. Organic Chemistry; L.G. Wade, 5 th edition, Pearson Publications, 2003 

2. Organic Chemistry, Clayden, Greeves, Warren, Oxford University Press, 2001

14. CHEM341 Physical Chemistry II

Credits: 3-1-0-3

Prerequisites: None

Unit I (Chemical Kinetics – 1) Rates of reaction - order and molecularity of reactions - rate law and rate constants - determination of rate law - first, second, third and fractional order of reactions - half lives - Arrhenius theory - types of reactions: approaching equilibrium, consecutive reactions, - steady state approximation - pre equilibria. 

Unit II (Chemical Kinetics – 2) Introduction to collisional theory of reactions - Lindemann Hinshelwood unimolecular reactions - complex reactions: reversible, parallel, competitive reactions, chain reactions - polymerization - explosion - oscillations - rapid reactions –. 

Unit III (Reaction in solutions) Comparison of rate between gas phase and in solution – factors governing rates of reaction in solution – theories of reaction rates applied to reactions in solutions – influence of liquid medium in rate – kinetic isotope effect – solvent isotope effect – linear free energy relationship 

Unit IV (Surface and Colloids) Surface tension, capillarity-structure of surface films-surfactants and micelles. Adsorption on surfaces - physisorption & chemisorption - desorption - adsorption isotherms: Gibbs, Langmuir, BET, other isotherms - measurement of surface area using adsorption isotherms, kinetics of homogeneous catalytic reaction - colloids: classification – preparation, purification, and stability of colloids 

Unit V (Reaction in the excited states) Photochemical reactions – excited electronic states – intermolecular and intramolecular deactivation kinetics of excited states - types of photochemical reaction – photoelectron- chemistry 

Textbook: 

J. Rajaram, J. Kuriakose, Kinetics and chemical transformation, MacMillan India Limited, 1993. 

Further Reading: 

1. G. L. Agarawal, Basic Chemical Kinetics, Tata McGraw Hill, 1990. 

2. Physical Chemistry, P.W. Atkins, 7 th edition, Oxford publication, 2006  

3. G. M. Barrow, Physical Chemistry, McGraw Hill, 1979.

15. CHEM302 Inorganic Chemistry III

Credits: 3-1-0-3

Prerequisites: None

Unit I (Chemistry and Periodic Trends among Metals) General periodic trends among metals; alkali metals; alkaline earth metals; coinage metals; zinc subgroup; scandium family and rare earths; actinide metals; transition metals - group 4 to 7, group 8 to 10. 

Unit II (Acids and Bases) Bronstat acids and bases: Bronstat acidy, periodic trends in Bronstat acidy, polyoxo compound formation; Lewis acids and bases: definitions, strengths, representative Lewis acids, heterogeneous acid-base reactions. 

Unit III (Solid State Chemistry) Inorganic Solids: Ionic solids, close packing, radius ratio, Structure of ionic crystals, ionic radii, lattice energy; crystal structure, defects structures, insulators, semiconductors and superconductivity. 

Unit IV (Main group Organometallics) Classification and structure, ionic and electron deficient compounds of groups 1, 2 and 12.; Electron deficient compounds of the boron group; Electron-precise compounds of the carbon group. Electron-rich compounds of the nitrogen group.

Unit V (Introduction to Bio-inorganic Chemistry) Pumps and transport proteins: Ion pumps, Oxygen transport; Enzymes and catalysis: Oxaloacetate decarboxylase, carboxy peptidase; Redox catalysis: cytochromes, nitrogen fixation, photosynthesis. 

Text book: 

D. F. Shriver, P. W. Atkins, C. H. Langford, Inorganic Chemistry, ELBS. 1990. 

Recommended Books: 

1. A. G. Sharpe, Inorganic Chemistry, 3 rd Edn., Addison-Wesley, 1999. 

2. J. D. Lee, A New Concise Inorganic Chemistry, 3rd Edn., ELBS, 1987. 

3. B. Douglas, D. McDaniel, J. Alexander, Concepts and Models of Inorganic Chemistry, 3rd Edn., John Wiley, 2001. 

4. W. L. Jolly, Modern Inorganic Chemistry, 2nd Edn., McGraw-Hill, 1991.

16. CHEM322 ORGANIC CHEMISTRY III

Credits: 3-1-0-3

Prerequisites: None

Unit I (Heterocycles) Chemistry of five and six–membered aromatic heterocycles with one hetero atom- synthesis and reactions of pyrrole, furan, thiophene, pyridine, indole, quinoline and isoquinoline and biologically important heterocycles (Chapter 27 of Bruice) 

Unit II (Carbohydrates and Lipids) Carbohydrates: Classification, configuration of aldoses and ketoses, reactions of monosaccharides, chain elangation, chain shortening, stereochemistry of glucose, the Fischer proof, cyclic structure of mono saccharides, formation of glycosides, reducing and non-reducing sugar, determination of ring size, di-saccharides and poly-saccharides. (Chapter 20 of Bruice.) Lipids: Fatty acids, waxes, fats and oils, membranes . (Chapter 24 of Bruice) 

Unit III (Amino acids, peptides and proteins) Classification and nomenclature of amino acids – configuration of amino acids, acid-base amino acids—isoelectric points—primary structure of peptides – end terminal analysis – peptides synthesis—secondary structure of proteins tertiary and quaternary structure of proteins. (Chapter 21 of Bruice.) 

Unit IV (Nucleosides, nucleotides and nucleic acids) Nucleosides and nucleotides, nucleic acids, helical forms of DNA, DNA replication. (Chapter 25 of Bruice). 

Unit V (Polymers and drugs) Introduction to synthetic polymers: General classes of synthetic polymers, chain growth polymers, stereo chemistry of polymerization, polymerization of dienes, co-polymers, step-growth polymers, physical properties of polymers, bio-degradable polymers. (Chapter 26 of Bruice) Introduction to organic chemistry of drugs: Naming drugs, lead compounds, molecular modification, random screening, serendipity in drug development, receptors, drugs as enzyme inhibitors, QSAR, anti-viral drugs (Chapter 30 of Bruice.) 

Text book: 

Organic Chemistry, P. Y. Bruice, Pearson Education, 3 rd edition, 2006 

Further Reading 

1. Organic Chemistry; L.G. Wade, 5 th edition, Pearson Publications, 2003 

2. Organic Chemistry, Clayden, Greeves, Warren, Oxford University Press, 2001

17. CHEM352 Analytical Chemistry

Credits: 3-1-0-3

prerequisites: None

UNIT I (Tools and Data Handling) Balances, burettes, volumetric flasks, pipettes, calibration of tools, sampling. Errors and Statistics: significant figures, rounding off, accuracy and precision, determinate and indeterminate errors, standard deviation, propagation of errors, confidence limit, test of significance, rejection of a result. 

UNIT II (Separation Techniques) Solvent Extraction: distribution Coefficient, distribution ratio, solvent extraction of metals, multiple batch extraction, counter current distribution. - Chromatographic Techniques: classification, theory of chromatographic separation, distribution coefficient, retention, sorption, efficiency and resolution. - Column, ion exchange, paper, TLC & HPTLC: techniques and application. - Gas Chromatography: retention time or volume, capacity ratio, partition coefficient, theoretical plate and number, separation efficiency and resolution, instrumentation and application. 

UNIT III (Spectroscopic Techniques) Electromagnetic radiation, absorption, and emission of radiation – instrumentation: sources, monochromators, detectors. - Flame spectrometry: flame emission, AAS, ICP, instrumentation and application. - Absorption spectrometry: UV-VIS, IR, instrumentation, techniques and applications. 

UNIT – IV Thermal and Radiochemical Techniques: Thermogravimetry: instrumentation and techniques, TGA curves, DTA and DSC, applications. Radiochemical methods: decay reactions, growth of radioactivity, radiation detectors, tracer techniques. 

UNIT V (Electroanalytical Techniques) Electrogravimetry, coulometry, voltam- metry, polarography, conductometry, instrumentation, techniques and application. 

Textbook: D. C. Harris, 

Quantitative Chemical Analysis, 4 th Ed., W. H. Freeman, 1995 

Further reading: 

G. D.Christian & J. E. O’Reily, Instrumental Analysis, 2 nd Ed., Allyn & Balon, 1986.