Course List

13. CHEM321 Organic chemistry II

Credits: 3-1-0-3

Prerequisites: None

Unit I (Reactions at sp hybridized carbon) Substitution reactions - SN1, SN2 reaction mechanism, factors influencing SN1 and SN2 reactions, elimination reaction E1, E2, E1cb reaction mechanisms factors affecting, substitutions vs eliminations. [Chapters 9, 10 and 11 of Bruice] 

Unit II (Organometallics of Groups I and II, boron, silicon, sulphur) Alkyl and aryl lithiums preparation and reactions, Grignard reagent synthesis and reactions, sulpur stabilized anions, sulphonium salts, sulphonium ylids, sulphur stabilizedcations carbonyl compounds, sulphoxides, borons - hydroborations, allyl and crotyl boranes, silicon - reactions of silanes and silyl enol ether. [Chapter 46 and 47 of Clayden] 

Unit III (Reactions of aldehydes and ketones) Reactions of carbonyl compounds with carbon, hydrogen, oxygen and nitrogen nucleo philes, reactions of α, β and unsaturated carbonyl compounds, reactions at the α-carbon[chapters 17 and 19 of Bruice] 

Unit IV (Reactions of carboxylic acids and their derivatives) Reactions of carboxylic acids and their derivatives with oxygen and nitrogen nucleophile– relative reactivities of carboxylic acid and its derivatives – general machanism of acylation reaction. [Chapter 16 of Bruice] 

Unit V (Introduction to spectroscopic identification of organic molecules) Mass spectrometry, infrared spectroscopy UV- Visible spectroscopy and NMR spectroscopy (Chapter 12 and 13 of Bruice) 

Text book: 

Organic Chemistry, P. Y. Bruice, Pearson Education, 3 rd edition, 2006 

Further Reading 

1. Organic Chemistry; L.G. Wade, 5 th edition, Pearson Publications, 2003 

2. Organic Chemistry, Clayden, Greeves, Warren, Oxford University Press, 2001